鈣調(diào)磷酸酶[1]（英語：Calcineurin，亦稱為蛋白磷酸酶3或蛋白磷酸酶2B，分別簡稱為PPP3CA與PP2B）其在體內(nèi)的作用為啟動T細(xì)胞并可以通過藥物來阻斷這一過程。
鈣調(diào)磷酸酶為很多種免疫抑制藥的作用對象如，環(huán)孢霉素,吡美莫司和他克莫司。
參考文獻(xiàn)
深入閱讀
- Crabtree GR. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999, 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
- Giri PR, Higuchi S, Kincaid RL. Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Biochem. Biophys. Res. Commun.. 1992, 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.
- Kincaid RL, Giri PR, Higuchi S, et al.. Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J. Biol. Chem.. 1990, 265 (19): 11312–9. PMID 2162844.
- Guerini D, Klee CB. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC298458/ Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain]. Proc. Natl. Acad. Sci. U.S.A.. 1990, 86 (23): 9183–7. doi:10.1073/pnas.86.23.9183. PMID 2556704. PMC 298458.
- Kincaid RL, Nightingale MS, Martin BM. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC282646/ Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin]. Proc. Natl. Acad. Sci. U.S.A.. 1988, 85 (23): 8983–7. doi:10.1073/pnas.85.23.8983. PMID 2848250. PMC 282646.
- Coghlan VM, Perrino BA, Howard M, et al.. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science. 1995, 267 (5194): 108–11. doi:10.1126/science.7528941. PMID 7528941.
- Griffith JP, Kim JL, Kim EE, et al.. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell. 1995, 82 (3): 507–22. doi:10.1016/0092-8674(95)90439-5. PMID 7543369.
- Shibasaki F, McKeon F. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2120616/ Calcineurin functions in Ca(2+)-activated cell death in mammalian cells]. J. Cell Biol.. 1995, 131 (3): 735–43. doi:10.1083/jcb.131.3.735. PMID 7593193. PMC 2120616.
- Muramatsu T, Kincaid RL. Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). Biochim. Biophys. Acta. 1993, 1178 (1): 117–20. doi:10.1016/0167-4889(93)90117-8. PMID 8392375.
- Cameron AM, Steiner JP, Roskams AJ, et al.. Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell. 1996, 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476.
- Kissinger CR, Parge HE, Knighton DR, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1996, 378 (6557): 641–4. doi:10.1038/378641a0. PMID 8524402.
- Wang MG, Yi H, Guerini D, et al.. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. Cytogenet. Cell Genet.. 1997, 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785.
- Shibasaki F, Kondo E, Akagi T, McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature. 1997, 386 (6626): 728–31. doi:10.1038/386728a0. PMID 9109491.
- Kashishian A, Howard M, Loh C, et al.. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J. Biol. Chem.. 1998, 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
- Wang HG, Pathan N, Ethell IM, et al.. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 1999, 284 (5412): 339–43. doi:10.1126/science.284.5412.339. PMID 10195903.
- Fuentes JJ, Genescà L, Kingsbury TJ, et al.. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet.. 2000, 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295.
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外部鏈接
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| 絲裂原活化蛋白 |
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| 鈣 |
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| G蛋白 |
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環(huán)磷酸腺苷: 異三聚G蛋白 (Gs/Gi) · 腺苷酸環(huán)化酶 · 環(huán)磷酸腺苷 · 3',5'-環(huán)磷酸腺苷磷酸二酯酶 · 蛋白激酶A
環(huán)磷酸鳥苷: 鳥苷酸環(huán)化酶 · 環(huán)磷酸鳥苷 · 3',5'-環(huán)磷酸鳥苷磷酸二酯酶 · 蛋白激酶G
β-γ復(fù)合體 Gβ (GNB1, GNB2, GNB3, GNB4, GNB5) · Gγ (GNGT1, GNGT2, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, BSCL2)
G蛋白偶聯(lián)受體激酶 · 磷酸腺苷活化蛋白激酶
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| 周期素 |
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| 脂類 |
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| 其它蛋白激酶 |
絲氨酸/蘇氨酸: 酪蛋白激酶 (1, 2) · 真核起始因子2激酶 (EIF2AK3) · 糖原合成酶激酶 (GSK1, GSK2, GSK-3, GSK3A, GSK3B) · IκB激酶 (CHUK, IKK2, IKBKG) · 白細(xì)胞介素1受體相關(guān)激酶 (IRAK1, IRAK2, IRAK3, IRAK4) · LIM激酶 (LIMK1, LIMK2) · P21活化激酶 (PAK1, PAK2, PAK3, PAK4) · Rho相關(guān)蛋白激酶 (ROCK1, ROCK2) · Ribosomal s6 kinase (RPS6KA1)
酪氨酸: ZAP70 · 局部粘著蛋白酪氨酸激酶 (PTK2, PTK2B) · BTK
both: 雙特異性激酶
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| 其它磷蛋白磷酸酶 |
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| 細(xì)胞凋亡 |
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| 三磷酸鳥苷結(jié)合蛋白調(diào)節(jié)劑 |
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| 其它 |
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參見相關(guān)疾病
B：trdu：iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk),
calc, lipd; path ( hedp, wntp, tgfp+ mapp, notp, jakp, fsap, hipp, tlrp)
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參考來源
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