葡萄糖-6-磷酸脫氫酶

葡萄糖-6-磷酸脫氫酶
	葡萄糖-6-磷酸脫氫酶結構（PDB 1qki）
命名
系統(tǒng)命名	D-glucose-6-phosphate:NADP+ 1-oxidoreductase
縮寫	G6PDH; GPD
別名	NADP-glucose-6-phosphate dehydrogenase; Zwischenferment; D-glucose 6-phosphate dehydrogenase; glucose 6-phosphate dehydrogenase (NADP); NADP-dependent glucose 6-phosphate dehydrogenase; 6-phosphoglucose dehydrogenase; Entner-Doudoroff enzyme; glucose-6-phosphate 1-dehydrogenase
識別碼
EC編號	1.1.1.49
CAS號	9001-40-5
數(shù)據(jù)庫
IntEnz	IntEnz瀏覽
BRENDA	BRENDA入口
ExPASy	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc	代謝路徑
PRIAM	概述
PDB	RCSB PDB PDBe PDBsum
基因本體	AmiGO / EGO
搜索
PMC	相關文獻
PubMed	相關文獻

葡萄糖-6-磷酸脫氫酶
	; PDB rendering based on 1qki.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1QKI, 2BH9, 2BHL
標識
代號	G6PD; G6PD1
擴展標識	遺傳學：305900 鼠基因：105979 同源基因：37906 GeneCards: G6PD Gene
EC編號	1.1.1.49
基因本體論描述
分子功能	· glucose-6-phosphate dehydrogenase activity; · binding; · glucose binding; · glucose binding; · oxidoreductase activity; · protein homodimerization activity; · NADP binding;
細胞成分	· cytoplasm; · centrosome; · cytosol; · cytosol; · internal side of plasma membrane; · intracellular membrane-bounded organelle;
生物過程	· cytokine production; · carbohydrate metabolic process; · pentose-phosphate shunt; · pentose-phosphate shunt; · lipid metabolic process; · cholesterol biosynthetic process; · NADPH regeneration; · glutathione metabolic process; · pentose-phosphate shunt, oxidative branch; · negative regulation of protein glutathionylation; · pentose biosynthetic process; · cellular response to oxidative stress; · erythrocyte maturation; · ribose phosphate biosynthetic process; · glucose 6-phosphate metabolic process; · oxidation-reduction process;
	Sources: Amigo / QuickGO
RNA表達模式
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A+醫(yī)學百科 >> 葡萄糖-6-磷酸脫氫酶

葡萄糖-6-磷酸脫氫酶（英語：glucose-6-phosphate dehydrogenase，EC 1.1.1.49）是一種以NAD⁺或NADP⁺為受體、作用于供體 CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：

葡萄糖-6-磷酸脫氫酶主要參與磷酸戊糖途徑，也能緩慢地作用在β-D-葡萄糖等其他糖類上。這種酶可由其底物葡萄糖-6-磷酸激活，如果人類表達葡萄糖-6-磷酸脫氫酶的基因 G6PD有缺陷，將會導致葡萄糖-6-磷酸脫氫酶缺乏癥，引發(fā)非免疫性溶血性貧血。葡萄糖-6-磷酸脫氫酶存在于眾多生物細胞內(nèi)，高等植物擁有數(shù)種葡萄糖-6-磷酸脫氫酶的蛋白異構體（protein isoform），它們分布于細胞質(zhì)基質(zhì)、和過氧化物酶體等細胞結構中。^[1]

參考文獻

↑ Corpas FJ et al.. A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes. Biochem. J.. 1998, 330 (7): 777–784.

Vulliamy T, Beutler E, Luzzatto L. Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene.. Hum. Mutat.. 1993, 2 (3): 159–67. doi:10.1002/humu.1380020302. PMID 8364584.
Mason PJ. New insights into G6PD deficiency.. Br. J. Haematol.. 1996, 94 (4): 585–91. PMID 8826878.
Wajcman H, Galactéros F. [Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents]. C. R. Biol.. 2004, 327 (8): 711–20. PMID 15506519.